Download Case Study: Yeast Cell Disruption by Scalable High-Intensity Ultrasound

Cell disruption (cell lysis) is necessary for many industries, including pharmaceutical, cosmetic, biotechnology, energy, nutraceutical, food & beverage and chemical. It is, for example, an important step in recombinant proteins production for medical applications. Chemical, enzymatic and conventional ultrasonic cell lysis methods are effective on laboratory scale but impractical for production.

Allied Innovative Systems (ALLIS) partnered with Industrial Sonomechanics (ISM) in order to determine the effectiveness of high-amplitude ultrasonic cell disruption and the feasibility of applying it on a large scale using Barbell Horn Ultrasonic Technology (BHUT).

In this case study we:

1. We compared chemical and ultrasonic cell lysis methods.
2. We determined whether the ultrasonic cell lysis process can be transfered from a laboratory to a pilot scale.
3. We determined the productivity gain factor and confirm that the process is directly scalable with BHUT.