Cell disruption (cell lysis) is necessary for many industries, including pharmaceutical, cosmetic, biotechnology, energy, nutraceutical, food & beverage and chemical. It is, for example, an important step in recombinant proteins production for medical applications. Chemical, enzymatic and conventional ultrasonic cell lysis methods are effective on laboratory scale but impractical for production.
Allied Innovative Systems (ALLIS) partnered with Industrial Sonomechanics (ISM) in order to determine the effectiveness of high-amplitude ultrasonic cell disruption and the feasibility of applying it on a large scale using Barbell Horn Ultrasonic Technology (BHUT).
In this case study we: